Frank’s Sign, a diagonal earlobe crease, has sparked debate regarding its link to cardiovascular issues. Studies suggest a modest association with coronary artery disease and stroke, but aging and other factors complicate the connection. Experts emphasize that it’s not a definitive diagnostic tool, advising focus on established risk factors like blood pressure and family history. Frank’s Sign, a diagonal earlobe crease, has sparked debate regarding its link to cardiovascular issues. Studies suggest a modest association with coronary artery disease and stroke, but aging and other factors complicate the connection. Experts emphasize that it’s not a definitive diagnostic tool, advising focus on established risk factors like blood pressure and family history.
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